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Estudio internacional para evaluar la terapia contra el VIH junto con interleucina-2 (rIL-2) en pacientes VIH-positivos

Concluido
Patrocinador(es) del estudio
National Institute of Allergy and Infectious Diseases (NIAID)

Números de identificación
NCT00004978, ESPRIT 001

Propósito del estudio

Propósito del estudio

El propósito de este estudio es ver si la administración de interleucina-2 (rIL-2), una proteína natural de la sangre que ayuda a fortalecer el sistema inmunitario, además del tratamiento contra el VIH, es eficaz para los pacientes infectados por ese virus. Los pacientes se mantendrán bajo control durante 5 años para estudiar los efectos de la interleucina-2 (rIL-2) a largo plazo sobre el avance de la infección causada por el VIH.

Afección:Fase:
Infecciones por el VIH
Fase 3

Detalles del estudio

Detalles del estudio

El tratamiento contra el virus se ha administrado con éxito a pacientes VIH-positivos y ha permitido mantener baja la concentración del VIH (carga viral) en la sangre. Sin embargo, no permite eliminar el virus totalmente y el sistema inmunitario de los pacientes VIH-positivos nunca se restablece por completo. Los médicos esperan que la administración de interleucina-2 (rIL-2), junto con el tratamiento contra el VIH, contribuya a fortalecer el sistema inmunitario de los pacientes y los mantenga sanos por más tiempo.Este es un estudio avanzado con un gran número de pacientes. Los pacientes se asignarán al azar para recibir o no la interleucina-2 (rIL-2). Todos los pacientes continuarán tomando sus combinaciones de medicamentos contra el VIH, sea que reciban o no la interleucina-2 (rIL-2) (sin embargo, en este estudio no se suministran los medicamentos contra el VIH). La interleucina-2 recombinante (rIL-2) se administra en inyección bajo la piel (subcutánea) dos veces al día, durante 5 días. Este ciclo se repite una vez cada 8 semanas. Los pacientes aprenderán a aplicarse las inyecciones de interleucina-2 (rIL-2). Los pacientes del grupo que no recibe la interleucina-2 (IL-2), no recibirán inyección alguna. Todos los pacientes deberán ir a la clínica una vez cada 4 meses para exámenes físicos y de sangre para controlar la carga viral y el recuento de células CD4. El control durará 5 años. Si los pacientes fueron asignados al grupo no tratado con interleucina-2 (rIL-2), no tendrán la opción de recibirla en ningún momento durante el estudio. Sin embargo, si al finalizar el estudio se encuentra que la interleucina-2 (rIL-2) es eficaz para el tratamiento del VIH, se ofrecerá a todos los pacientes.


Criterios de inclusión

Criterios de inclusión

    Los pacientes podrán participar si:
    • Son VIH-positivos.
    • Tienen un recuento de células CD4 de 300/mm3 ó más, durante los 45 días anteriores al ingreso al estudio.
    • Reciben un tratamiento combinado contra el VIH o comienzan a tomarlo en el momento de iniciarse el estudio.
    • Tienen por lo menos 18 años de edad.

Criterios de exclusión

    Los pacientes no podrán participar en este estudio si:
    • Han recibido antes interleucina-2 (IL-2).
    • Tienen una clase de cáncer que requiere quimioterapia.
    • Durante el año pasado presentaron indicios de una enfermedad clínica relacionada con cualquier enfermedad que define el diagnóstico de SIDA u otros trastornos específicos como la quemadura de sapo (herpes zoster) o la infección causada por el parásito Trypanosoma cruzi (conocida como enfermedad de Chagas), que produce fiebre y problemas del hígado, el bazo y el corazón. (Este estudio ha sido modificado. Anteriormente, los pacientes no podían participar si tenían un historial de cualquier enfermedad que define el diagnóstico de SIDA u otros trastornos específicos.)
    • En los 45 días anteriores al inicio del estudio, han usado determinados medicamentos, como cortisona, u otros que afectan al sistema inmunitario.
    • Tienen un trastorno del sistema nervioso que requiere medicamentos contra las convulciones.
    • Tienen una enfermedad en que el sistema inmunitario se ataca a sí mismo o una enfermedad inflamatoria, como una inflamación intestinal (i.e., la enfermedad de Crohn o colitis ulcerosa), psoriasis, neuritis óptica, o cualquier enfermedad en que el sistema inmunitario se ataca a sí mismo o una enfermedad inflamatoria con complicaciones que resulten potencialmente mortal.
    • Están embarazadas o dando el pecho.
Contact information

Centros de estudio/contactos

California

VA Greater Los Angeles Healthcare System, Infectious Diseases Section CRS, Los Angeles, California, 90073, United States

Dr. M. Estes Med. Practice CRS, Mill Valley, California, 94941-3013, United States

Dr. Robert Scott Med. Practice CRS, Oakland, California, 94609, United States

East Bay AIDS Ctr. CRS, Oakland, California, 94705, United States

Dr. Shawn Hassler Med. Practice CRS, San Francisco, California, 94102, United States

Positive Health Program Clinic (San Francisco Gen. Hosp.) CRS, San Francisco, California, 94110-0242, United States

Positive Health Practice West/ Dr. Steve Deeks CRS, San Francisco, California, 94110, United States

Dr. William Owen Med. Practice CRS, San Francisco, California, 94114-1010, United States

Dr. Martin Mass Med. Practice CRS, San Francisco, California, 94114, United States

San Francisco VAMC, Infectious Diseases Clinic CRS, San Francisco, California, 94121, United States

UCSF PHP, Gen. Internal Medicine Practice CRS, San Francisco, California, 94143, United States

Castro-Mission Health Ctr. CRS, San Francisco, California, 94144, United States

Dr. Virginia Cafaro Med. Practice CRS, San Francisco, California, 94144, United States

Colorado

Denver Infectious Diseases Consultants CRS, Denver, Colorado, 80204-4507, United States

Denver Public Health CRS, Denver, Colorado, 80204-4507, United States

Univ. of Colorado Health Science Ctr. CRS, Denver, Colorado, 80204-4507, United States

District of Columbia

Whitman-Walker Clinic CRS, Washington, District of Columbia, 20009, United States

George Washington Univ. Med. Ctr. Infectious Diseases - Clinical Trials Unit CRS, Washington, District of Columbia, 20037, United States

Walter Reed Army Med. Ctr., Infectious Disease Clinic CRS, Washington, District of Columbia, 20307, United States

Washington DC VAMC, Washington Regional AIDS Program, Infectious Diseases CRS, Washington, District of Columbia, 20422, United States

Dr. Timothy A. Price Med. Practice CRS, Washington, District of Columbia, 20422, United States

Florida

Miami VAMC CRS, Miami, Florida, 33125, United States

Univ. of Miami, Infectious Diseases Clinical Research Unit CRS, Miami, Florida, 33136, United States

Georgia

ARCA, Central Clinc CRS, Atlanta, Georgia, 30308, United States

Emory Univ. Crawford Long Hosp. CRS, Atlanta, Georgia, 30308, United States

Atlanta VAMC CRS, Decatur, Georgia, 30033, United States

Illinois

Klein & Slotten Medical Associates CRS, Chicago, Illinois, 60610, United States

Jesse Brown VAMC CRS, Chicago, Illinois, 60612, United States

Univ. of Illinois Family Ctr. for Infectious Disease CRS, Chicago, Illinois, 60612, United States

Lakeshore Infectious Disease Associates CRS, Chicago, Illinois, 60657, United States

North Side Family Medicine CRS, Chicago, Illinois, 60657, United States

Northwestern Memorial Physicians Group CRS, Chicago, Illinois, 60657, United States

Louisiana

Med. Ctr. of Louisiana at New Orleans, HIV Outpatient Clinics CRS, New Orleans, Louisiana, 70112, United States

Tulane University Health Sciences Center, Louisiana Community AIDS Research Program(LaCARP) CRS, New Orleans, Louisiana, 70112, United States

New Orleans VAMC CRS, New Orleans, Louisiana, 70146, United States

Maryland

NIH Clinical Ctr., NIAID HIV Clinic CRS, Bethesda, Maryland, 20814-9692, United States

National Naval Med. Ctr., Infectious Diseases Special Immunology Clinic CRS, Bethesda, Maryland, 208995000, United States

Michigan

Henry Ford Hosp. CRS, Detroit, Michigan, 208995000, United States

Wayne State Univ. CRS, Detroit, Michigan, 208995000, United States

St. John Hosp. & Med. Ctr., Infectious Diseases Dept. CRS, Grosse Pointe Woods, Michigan, 48236, United States

William Beaumont Hosp., Infectious Disease Research CRS, Royal Oak, Michigan, 48073, United States

Minnesota

Abbott Northwestern Hosp., Clinic 42 CRS, Minneapolis, Minnesota, 55404, United States

Mayo Clinic INSIGHT CRS, Rochester, Minnesota, 55905, United States

New Jersey

Cooper Univ. Hosp. CRS, Camden, New Jersey, 07754, United States

ID Care Inc. - Hillsborough CRS, Hillsborough, New Jersey, 08844, United States

Jersey Shore Univ. Med. Ctr. CRS, Neptune, New Jersey, 07754, United States

New Jersey Community Research Initiative, Jeffrey Bomser Clinic CRS, Newark, New Jersey, 07103, United States

Cathedral Healthcare System, St. Michael's Med. Ctr. CRS, Newark, New Jersey, 07103, United States

St. Joseph's Hosp. & Med. Ctr. of New Jersey CRS, Paterson, New Jersey, 07103, United States

Raritan Bay Med. Ctr., Perth Amboy Division CRS, Perth Amboy, New Jersey, 08861, United States

ID Care - Randolph CRS, Randolph, New Jersey, 07869, United States

Infectious Disease Specialists of N.J., North Jersey Community Research Initiative CRS, Union, New Jersey, 07083, United States

The Early Intervention Program at Kennedy Hosp. CRS, Voorhees, New Jersey, 08043, United States

New York

Jacobi Med. Ctr., Ambulatory Care Pavillion CRS, Bronx, New York, 10461, United States

Bronx VAMC CRS, Bronx, New York, 10468, United States

St. Vincent Hosp. & Med. Ctr. CRS, New York, New York, 10011, United States

Harlem Hospital Ctr./Columbia University CRS (Gordin CTU), New York, New York, 10037, United States

Oregon

Oregon Health & Sciences Univ. Internal Medicine (L-475) CRS, Portland, Oregon, 97201, United States

Multnomah County Health Dept., HIV Health Services Ctr. CRS, Portland, Oregon, 97204, United States

The Research & Education Group-Portland CRS, Portland, Oregon, 97209, United States

Providence Portland Med. Ctr., Ambulatory Care and Education Ctr. CRS, Portland, Oregon, 97213, United States

Kaiser Immune Deficiency Clinic of Portland CRS, Portland, Oregon, 97227, United States

Legacy Clinic Emanuel CRS, Portland, Oregon, 97301, United States

Salem Hosp. CRS, Salem, Oregon, 97301, United States

Kaiser Permanente Lancaster Clinic CRS, Salem, Oregon, 97305, United States

Pennsylvania

Temple Univ. School of Medicine CRS, Philadelphia, Pennsylvania, 19140, United States

Texas

Michael E. DeBakey VAMC CRS, Houston, Texas, 77030, United States

Northwest Clinic CRS, Houston, Texas, 77030, United States

Thomas Street Clinic CRS, Houston, Texas, 77030, United States

Univ. Clinical Research Ctr., Memorial Hermann Hosp. CRS, Houston, Texas, 77030, United States

Legacy Community Health Services, Inc., Montrose Clinic, Inc., Houston, Texas, 77030, United States

South Texas Veterans Health Care System, Immunosuppression Clinic CRS, San Antonio, Texas, 78284, United States

Virginia

Hanover Med. Park (Mechanicsville, VA) CRS, Mechanicsville, Virginia, 23116, United States

Naval Med. Ctr. Portsmouth CRS, Portsmouth, Virginia, 23708, United States

CrossOver Health Ctr. CRS, Richmond, Virginia, 23224, United States

South Richmond Health Care Ctr. CRS, Richmond, Virginia, 23224, United States

Hunter Holmes McGuire VAMC CRS, Richmond, Virginia, 23249, United States

Virginia Commonwealth Univ. Medical Ctr. CRS, Richmond, Virginia, 23249, United States

Buenos Aires

Hosp. de Clinicas Jose de San Martin, Div. Infectologia CRS, Ciudad de Buenos Aires, Buenos Aires, 1020, Argentina

Hosp. Italiano de Buenos Aires, Infectious Diseases Section CRS, Ciudad de Buenos Aires, Buenos Aires, 1199, Argentina

Hosp. Gen. de Agudos JM Ramos Mejia, Servicio de Inmunocomprometidos CRS, Ciudad de Buenos Aires, Buenos Aires, 1221, Argentina

Hospital de Infecciosas F.J. Muniz CRS, Ciudad de Buenos Aires, Buenos Aires, 1282, Argentina

Funcei Crs, Ciudad de Buenos Aires, Buenos Aires, 1425, Argentina

Hosp. Gen. de Agudos Juan A. Fernandez CRS, Ciudad de Buenos Aires, Buenos Aires, 1425, Argentina

Hosp. Gen. de Agudos 'Teodoro Alvarez' CRS, Ciudad de Buenos Aires, Buenos Aires, 1425, Argentina

Hospital Nacional Professor Alejandro Posadas CRS, El Palomar, Buenos Aires, 1706, Argentina

Hospital Interzonal de Agudos Oscar Alende, Sala de Infectologia CRS, Mar del Plata, Buenos Aires, 7600, Argentina

Provincia de Santa Fe

Caici Crs, Rosario, Provincia de Santa Fe, 2000, Argentina

Hosp. Rawson CRS, Cordoba, Provincia de Santa Fe, 5000, Argentina

Hosp. Interzonal de Agudos San Juan de Dios CRS, La Plata, Provincia de Santa Fe, 1900, Argentina

Hosp. Central, Immunology Dept. CRS, Mendoza, Provincia de Santa Fe, 5500, Argentina

Australian Capital Territory

Interchange General Practice CRS, Canberra, Australian Capital Territory, 2601, Australia

Canberra Hosp., Canberra Sexual Health Clinic CRS, Woden, Australian Capital Territory, 2606, Australia

New South Wales

Burwood Road Gen. Practice CRS, Burwood, New South Wales, 2134, Australia

St. Vincent's Hospital CRS, Darlinghurst, New South Wales, 2010, Australia

Taylor Square Private Clinic CRS, Darlinghurst, New South Wales, 2010, Australia

Holdsworth House Gen. Practice CRS, Darlinghurst, New South Wales, 2010, Australia

John Hunter Hosp., Immunology & Infectious Diseases Unit CRS, Newcastle, New South Wales, 2305, Australia

407 Doctors CRS, Surry Hills, New South Wales, 2010, Australia

Albion Street Ctr. CRS, Surry Hills, New South Wales, 2010, Australia

Queensland

Queensland Health - AIDS Med. Unit CRS, Brisbane, Queensland, 2010, Australia

Cairns Base Hosp., Sexual Health Services CRS, Cairns, Queensland, 4870, Australia

Gladstone Road Medical Ctr. CRS, Highgate Hill, Queensland, 4101, Australia

Nambour Gen. Hosp. CRS, Nambour, Queensland, 4560, Australia

South Australia

Royal Adelaide Hosp. CRS, Adelaide, South Australia, 5000, Australia

The Care & Prevention Programme CRS, Adelaide, South Australia, 5000, Australia

Victoria

Carlton Clinic CRS, Carlton, Victoria, 5000, Australia

The Alfred Hosp., Clinical Research - Infectious Diseases Unit CRS, Melbourne, Victoria, 3004, Australia

Prahran Market Clinic CRS, Melbourne, Victoria, 3004, Australia

Northcote Clinic CRS, Northcote, Victoria, 3070, Australia

Royal Melbourne Hosp., Victorian Infectious Diseases Service CRS, Parkville, Victoria, 3052, Australia

The Ctr. Clinic INSIGHT CRS, St. Kilda, Victoria, 3052, Australia

Western Australia

Royal Perth Hospital CRS, Perth, Western Australia, 3052, Australia

Gold Coast Sexual Health Clinic CRS, Miami, Queensland, Western Australia, 3052, Australia

Univ. of Vienna Med. School, Div. of Allergy, Immunology & Infectious Diseases - Sued B CRS, Vienna, Western Australia, A-1090, Austria

SMZ Baumgartner Hoehe, Immunambulanz Pavillion Wienerwald Parterre CRS, Wien, Western Australia, A-1140, Austria

Ctr. Hospitalier Universitaire, St Pierre, Div. of Infectious Diseases (PL5) CRS, Bruxelles, Western Australia, A-1140, Belgium

Sao Paulo

Centro de Referencia e Treinamento em DST/AIDS - Sao Paulo CRS, Vila Mariana, Sao Paulo, 04121-000, Brazil

Instituto de Infectologia Emilio Ribas CRS, Sao Paulo, Sao Paulo, 01246-900, Brazil

Universidade Federal de Sao Paulo,IDIPA-Instituto Paulista de Doencas Infecciosas e Parasitarias CRS, Sao Paulo, Sao Paulo, 04040-002, Brazil

Alberta

Univ. of Alberta Hosp., Clinical Research Office CRS, Edmonton, Alberta, 04040-002, Canada

British Columbia

Cool Aid Community Health Ctr. CRS, Victoria, British Columbia, 04040-002, Canada

Nova Scotia

Q.E. II Health Sciences Ctr., Captial District Authority, Victoria Gen. Hosp. CRS, Halifax, Nova Scotia, 04040-002, Canada

Ontario

McMaster Univ. Med. Ctr. Hamiton Health Sciences, SIS Clinic CRS, Hamilton, Ontario, 04040-002, Canada

St. Joseph's Health Ctr. of London, HIV Care Programme CRS, London, Ontario, N5Y 3H6, Canada

Ottawa Hosp., Gen. Campus CRS, Ottawa, Ontario, K1H 8L6, Canada

The HAVEN Program, Sudbury Regional Hosp., Laurentian Site CRS, Sudbury, Ontario, P3E 5J1, Canada

Toronto Gen. Hosp. Infectious Diseases CRS, Toronto, Ontario, P3E 5J1, Canada

Windsor Regional Hosp., HIV Care Program CRS, Windsor, Ontario, P3E 5J1, Canada

Quebec

CHUS - Hopital Fleurimont, Centre de Recherche Clinique CRS, Fleurimont, Quebec, J1H 5N4, Canada

Hopital Maisonneuve-Rosemont, Dept. de Microbiologie CRS, Montreal, Quebec, H1T 2M4, Canada

CHUM - Campus Notre-Dame CRS, Montreal, Quebec, H2L 4M1, Canada

Royal Victoria Hosp., Montreal Chest Institute CRS, Montreal, Quebec, H2L 4M1, Canada

Centre Hospitalier Universitaire de Quebec - CHUL, Centre de Recherche en Indectiologie CRS, Sainte-Foy, Quebec, H2L 4M1, Canada

Saskatchewan

Royal Univ. Hosp. CRS, Saskatoon, Saskatchewan, S7N 0W8, Canada

Aalborg Hosp., Dept. of Infectious Diseases CRS, Aalborg, Saskatchewan, S7N 0W8, Denmark

Skejby Sygehus, Department of Infectious Diseases Q (ambulatoriet) CRS, Aarhus, Saskatchewan, DK-8200, Denmark

Rigshospitalet, Department of Infectious Diseases, M5112 CRS, Copenhagen, Saskatchewan, DK-8200, Denmark

Hvidovre Univ. Hosp., Dept. of Infectious Diseases CRS, Hvidovre, Saskatchewan, DK-8200, Denmark

Odense Univ. Hosp., Med. Dept. C CRS, Odense, Saskatchewan, DK-8200, Denmark

Pringy

Centre Hospitalier de la Region Annecienne, Service des Maladie Infectieuses CRS, Cedex, Pringy, DK-8200, France

CHRU d'Angers, Service de Maladies Infectieuses CRS, Angers, Pringy, 49033, France

Hopital Saint-Jacques, Service des Maladies Infectieuses et Tropicales CRS, Besancon, Pringy, 25030, France

Hopital Avicenne, Service de Medecine B CRS, Bobigny, Pringy, 93009, France

Hopital Antoine Beclere Service d'Immunologie Clinique CRS, Clamart, Pringy, 92141, France

Hopital Louis Mourier, Service de Medecine Interne CRS, Colombes, Pringy, 92701, France

Hopital Henri Mondor, Immunopathologie Clinique CRS, Creteil, Pringy, 94010, France

Hopital Raymond Poincare - Vidal 2, Service des Maladies Infectieuses et Tropicales CRS, Garches, Pringy, 92380, France

Hopital de Bicetre, Service de Medecine Interne CRS, Le Kremlin-Bicetre, Pringy, 94275, France

Hopital Sainte Marguerite, CISIH Hopital de Jour CRS, Marseille, Pringy, 13009, France

Hopital de la Conception, Service des Maladies Infectieuses CRS, Marseille, Pringy, 13385, France

Hopital Gui de Chauliac, Service des Maladies Infectieuses et Tropicales CRS, Montpellier, Pringy, 34295, France

Hopital de l'Archet 1, Service de Medecine Interne 2 Hematologie Clinique CRS, Nice, Pringy, 06202, France

Hopital Saint-Antoine, Service de Maladies Infectieuses CRS, Paris, Pringy, 75012, France

Hopital de La Salpetriere, Service de Medecine Interne CRS, Paris, Pringy, 75651, France

Hopital Cochin, Service de Medecine Interne 2 CRS, Paris, Pringy, 75674, France

Hopital Necker, Service des Maladies Infectieuses CRS, Paris, Pringy, 75743, France

Hopital Europeen Georges Pompidou, Service d'Immunologie Clinique CRS, Paris, Pringy, 75908, France

Hopital Tenon, Service de Maladies Infectieuses et Tropicales CRS, Paris, Pringy, 75970, France

C.H.U. Bichat - Claude Bernard Service des Maladies Infectieuses et Tropicales CRS, Paris, Pringy, 75970, France

CHRU de Strasbourg (France) CRS, Strasbourg, Pringy, 67091, France

Hopital Foch, Service de Medecine Interne CRS, Suresenes, Pringy, 92151, France

Univ. Hosp. Charite, Dept of Infectious Diseases CRS, Berlin, Pringy, 13353, Germany

Ruhr-Univ., Interdiszipl. Immunolog. Ambulanz CRS, Bochum, Pringy, 13353, Germany

Medizinische Universitaetsklinik - Bonn, Immunologische Ambulanz CRS, Bonn, Pringy, 53105, Germany

Ctr. for HIV & Hepatogastroenterology, HIV Specialised Practice (Private Practice) CRS, Duesseldorf, Pringy, 40237, Germany

Johann Wolfgang Goethe Univ. Hosp., Infektionsambulanz CRS, Frankfurt, Pringy, 60590, Germany

IPM Study Ctr. (Hamburg) CRS, Hamburg, Pringy, 60590, Germany

Univ. Hosp. Heidelberg, Dept. of Dermatology CRS, Heidelberg, Pringy, 69115, Germany

Klinik I fur Innere Medizin der Universitat zu Koln, Studienburo fur Infektiologie u. HIV CRS, Koln, Pringy, 69115, Germany

Klinikum Innenstadt, Infektionsambulanz und Tagesklinik CRS, Munchen, Pringy, 69115, Germany

Univ. of Wuerzburg, Medizinische Poliklinik, Schwerpunkt Hepatologie/Infektiologie CRS, Wuerzburg, Pringy, 69115, Germany

St. James' Hosp., Guide Clinic CRS, Dublin, Pringy, 69115, Ireland

Rambam Med. Ctr., Immunology, Allergy & AIDS Institute, B. Rappaport Faculty of Medicine, Technion, Haifa, Pringy, 31096, Israel

Kaplan Med. Ctr., Ben Ari Institute of Clinical Immunology CRS, Rehovot, Pringy, 31096, Israel

Tel Aviv Sourasky Med. Ctr., Clinical Immunology Unit and AIDS Ctr. CRS, Tel Aviv, Pringy, 64239, Israel

Civili di Brescia, 1st Division of Infectious Diseases CRS, Brescia, Pringy, 25123, Italy

Civili di Brescia, Dept of Infectious & Tropical Disease, Hosp.Spedali Civili of Brescia CRS, Brescia, Pringy, 25123, Italy

Ospedale S. Maria Annunziata, U.O. Malattie Infettive CRS, Firenze, Pringy, 50011, Italy

Ospedale San Raffaele, Centro San Luigi - Divisione Malattie Infettive CRS, Milano, Pringy, 50011, Italy

Univ. of Milan, Ospedale Luigi Sacco, Institute of Infectious and Tropical Diseases CRS, Milano, Pringy, 50011, Italy

Universita degli Studi di Modena e Reggio Emilia, Clinica delle Malattie Infettive e Tropicali CRS, Modena, Pringy, 50011, Italy

San Matteo Hospital - University of Pavia, Division of Infectious and Tropical Diseases CRS, Pavia, Pringy, 27100, Italy

Universita La Sapienza, Clinica Universita La Sapienza CRS, Roma, Pringy, 00185, Italy

Osaka National Hosp. AIDS Ctr., Clinical Research Institute CRS, Osaka, Pringy, 00185, Japan

International Med. Ctr. of Japan CRS, Tokyo, Pringy, 00185, Japan

Univ. of Tokyo, Research Hosp. of the Institute of Medical Science CRS, Tokyo, Pringy, 00185, Japan

Univ. Hosp. Ctr. of the Med. School of Casablanca, Infectious Diseases Unit CRS, Casablanca, Pringy, 00185, Morocco

OLVG -- locatie Prinsengracht, Dept. of Internal Medicine II CRS, Amsterdam, Pringy, 1017 JZ, Netherlands

Academisch Medisch Centrum CRS, Amsterdam, Pringy, 1150 AZ, Netherlands

Stichting Medisch Centrum Jan van Goyen, Dept. of Internal Medicine CRS, Amsterdam, Pringy, 1150 AZ, Netherlands

Groningen Univ. Hosp., Department of Internal Medicine CRS, Groningen, Pringy, 9713 GZ, Netherlands

Kennemer Gasthuis, Lokatie EG CRS, Haarlem, Pringy, 9713 GZ, Netherlands

St. Elisabeth Ziekenhuis CRS, Tilburg, Pringy, 9713 GZ, Netherlands

Ulleval Hosp., Dept. of Infectious Diseases CRS, Oslo, Pringy, 9713 GZ, Norway

Szpital Specjalistyczny, Osrodek Diagnostyki i Terapii AIDS CRS, Chorzow, Pringy, 41-500, Poland

Pomeranian Academy of Medicine (PAM), Dept. of Infectious Diseases and Hepatology CRS, Szczecin, Pringy, 71-455, Poland

Wojewodzki Szpital Zakazny CRS, Warsaw, Pringy, 01-201, Poland

Wroclaw Univ., School of Med., Dept. of Infectious Diseases, Liver Diseases and AIDS CRS, Wroclaw, Pringy, 51-171, Poland

Hospital de Cascais, HDDI, Departamento Medicina Interna CRS, Cascais, Pringy, 2775, Portugal

Hosp. de Egas Moniz, Servicio de Infecciologia e Medicina Tropical CRS, Lisboa, Pringy, 1349-019, Portugal

Hosp. de Santa Maria, Servico de Doencas Infecciosas CRS, Lisboa, Pringy, 1349-019, Portugal

Tan Tock Seng Hosp., Infectious Diseases Research Ctr. CRS, Singapore, Pringy, 308433, Singapore

Guipuzcoa

Hosp. Donostia CRS, San Sebastian, Guipuzcoa, E-20011, Spain

Hosp. Juan Canalejo, Dept. of Internal Medicine CRS, A Coruna, Guipuzcoa, E-20011, Spain

Hosp. Santa Creu i Sant Pau, Servicio de Medicina Interna CRS, Barcelona, Guipuzcoa, E-08025, Spain

Hosp. Clinico de Barcelona CRS, Barcelona, Guipuzcoa, E-08036, Spain

Hosp. del Mar, Internal Medicine-Infectious Diseases CRS, Barcelona, Guipuzcoa, E-08036, Spain

Hosp. Universitari Germans Trias i Pujol, HIV Unit and Retrovirology Lab. CRS, Barcelona, Guipuzcoa, E-08036, Spain

Hosp. Universitario Gregorio Maranion, Microbiology & Infectious Diseases Unit CRS, Madrid, Guipuzcoa, E-28007, Spain

Centro de Investigacion Carlos III, Infectious Diseases Dept. CRS, Madrid, Guipuzcoa, E-28029, Spain

Hosp. Severo Ochoa, Internal Medicine and Infectious Diseases CRS, Madrid, Guipuzcoa, E-28911, Spain

Hosp. 12 de Octubre, Pabellon de Medicina Communitaria CRS, Madrid, Guipuzcoa, E-28911, Spain

Hosp. Clinico San Carlos CRS, Madrid, Guipuzcoa, E-28911, Spain

Hosp. la Princesa, Internal Medicine and Infectious Diseases Service CRS, Madrid, Guipuzcoa, E-28911, Spain

Hosp. Ramon y Cajal (Madrid) CRS, Madrid, Guipuzcoa, E-28911, Spain

Hosp. Universitario La Paz CRS, Madrid, Guipuzcoa, E-28911, Spain

Hosp. Universitario Principe de Asturias CRS, Madrid, Guipuzcoa, E-28911, Spain

Hosp. Universitario Morales Meseguer CRS, Murcia, Guipuzcoa, E-28911, Spain

Hosp. Virgen del Rocio, Infectious Diseases Service CRS, Sevilla, Guipuzcoa, E-41013, Spain

Karolinska Univ. Hosp. Huddinge, Dept. of Infectious Diseases CRS, Stockholm, Guipuzcoa, SE-141 86, Sweden

Venhalsan, Soder Hosp., Dept. of Infectious Diseases, Karolinska Univ. Hosp. CRS, Stockholm, Guipuzcoa, SE-141 86, Sweden

Ticino

Regional Hosp. of Lugano (Sede Civico), Ospedale Civico di Lugano, Infectious Diseases Unit CRS, Lugano, Ticino, CH-6903, Switzerland

Ratchathewi

Siriraj Hosp., Mahidol Univ. INSIGHT CRS, Bangkok, Ratchathewi, 10700, Thailand

Chulalongkorn Univ. Hosp., HIV-NAT Research Collaboration CRS, Bangkok, Ratchathewi, 10700, Thailand

Chiang Rai Regional Hosp. INSIGHT CRS, Chiangrai, Ratchathewi, 10700, Thailand

Chonburi Regional Hosp., Dept. of Internal Medicine CRS, Chonburi, Ratchathewi, 10700, Thailand

Khon Kaen Univ., Srinagarind Hosp., Div. of Infectious Diseases & Tropical Medicine, Dept. of Medici, Khon Kaen, Ratchathewi, 40002, Thailand

Brighton

Brighton & Sussex Univ. Hosp. NHS Trust, HIV Research Office CRS, Elm Grove, Brighton, BN2 1ES, United Kingdom

Northern Ireland

Royal Victoria Hosp. Dept. of Genitourinary Medicine CRS, Belfast, Northern Ireland, BN2 1ES, United Kingdom

Oxford

Churchill Hosp. John Warin Ward CRS, Headington, Oxford, OX3 9DU, United Kingdom

Scotland

Western Gen. Hosp., Regional Infectious Diseases Unit CRS, Edinburgh, Scotland, OX3 9DU, United Kingdom

Gartnaval Gen. Hosp., Brownlee Ctr. CRS, Glasgow, Scotland, OX3 9DU, United Kingdom

Heartlands Hosp. Dept. of Infection & Tropical Disease Outpatients CRS, Birmingham, Scotland, B9 5ST, United Kingdom

Royal Devon & Exeter NHS Foundation Trust, Heavitree Hosp., Dept. of GU Medicine CRS, Exeter, Scotland, EX1 2ED, United Kingdom

Leicester Royal Infirmary, Dept. of Infection & Tropical Medicine CRS, Leicester, Scotland, LE1 5WW, United Kingdom

Royal London Hosp., Ambrose King Ctr. CRS, London, Scotland, E1 1BB, United Kingdom

St. Thomas' Hosp., Dept. of GU Medicine CRS, London, Scotland, SE1 7EH, United Kingdom

St. George's Hosp. Clinical Infection UnitCRS, London, Scotland, SW17 0RE, United Kingdom

Chelsea & Westminster Hosp., St. Stephens Ctr. CRS, London, Scotland, SW17 0RE, United Kingdom

King's College Hosp., Caldecot Ctr. Dept. of Sexual Health CRS, London, Scotland, SW17 0RE, United Kingdom

Royal Free Hosp., Dept. of Infection & Immunity, Ian Charleson Day Ctr. CRS, London, Scotland, SW17 0RE, United Kingdom

St. Bartholomew's Hosp., Infection & Immunity Clinical Group CRS, London, Scotland, SW17 0RE, United Kingdom

St. Mary's Hosp. of London, Imperial College School of Medicine CRS, London, Scotland, SW17 0RE, United Kingdom

Univ. College London Med. School, Ctr. for Sexual Health & HIV Research CRS, London, Scotland, SW17 0RE, United Kingdom

Newcastle Gen. Hosp., Dept of Infection & Tropical Medicine CRS, Newcastle Upon Tyne, Scotland, NE4 6BE, United Kingdom

Edith Cavell Hosp. Dept. of Sexual Health, Clinic E CRS, Peterborough, Scotland, NE4 6BE, United Kingdom

Royal Hallamshire Hosp., Dept. of GU Medicine Communicable Diseases Unit CRS, Sheffield, Scotland, S10 2JF, United Kingdom

Actualizado: 13 de octubre del 2004