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Ensayos clínicos

Ensayos clínicos

Estudio internacional para evaluar la terapia contra el VIH junto con interleucina-2 (rIL-2) en pacientes VIH-positivos

Patrocinador(es) del estudio: National Institute of Allergy and Infectious Diseases (NIAID)
Números de identificación: NCT00004978, ESPRIT 001
  • Concluido

Propósito del estudio

El propósito de este estudio es ver si la administración de interleucina-2 (rIL-2), una proteína natural de la sangre que ayuda a fortalecer el sistema inmunitario, además del tratamiento contra el VIH, es eficaz para los pacientes infectados por ese virus. Los pacientes se mantendrán bajo control durante 5 años para estudiar los efectos de la interleucina-2 (rIL-2) a largo plazo sobre el avance de la infección causada por el VIH.

Afección:Fase:
Infecciones por el VIH
Fase 3

Detalles del estudio

El tratamiento contra el virus se ha administrado con éxito a pacientes VIH-positivos y ha permitido mantener baja la concentración del VIH (carga viral) en la sangre. Sin embargo, no permite eliminar el virus totalmente y el sistema inmunitario de los pacientes VIH-positivos nunca se restablece por completo. Los médicos esperan que la administración de interleucina-2 (rIL-2), junto con el tratamiento contra el VIH, contribuya a fortalecer el sistema inmunitario de los pacientes y los mantenga sanos por más tiempo.Este es un estudio avanzado con un gran número de pacientes. Los pacientes se asignarán al azar para recibir o no la interleucina-2 (rIL-2). Todos los pacientes continuarán tomando sus combinaciones de medicamentos contra el VIH, sea que reciban o no la interleucina-2 (rIL-2) (sin embargo, en este estudio no se suministran los medicamentos contra el VIH). La interleucina-2 recombinante (rIL-2) se administra en inyección bajo la piel (subcutánea) dos veces al día, durante 5 días. Este ciclo se repite una vez cada 8 semanas. Los pacientes aprenderán a aplicarse las inyecciones de interleucina-2 (rIL-2). Los pacientes del grupo que no recibe la interleucina-2 (IL-2), no recibirán inyección alguna. Todos los pacientes deberán ir a la clínica una vez cada 4 meses para exámenes físicos y de sangre para controlar la carga viral y el recuento de células CD4. El control durará 5 años. Si los pacientes fueron asignados al grupo no tratado con interleucina-2 (rIL-2), no tendrán la opción de recibirla en ningún momento durante el estudio. Sin embargo, si al finalizar el estudio se encuentra que la interleucina-2 (rIL-2) es eficaz para el tratamiento del VIH, se ofrecerá a todos los pacientes.

Criterios de inclusión

    Los pacientes podrán participar si:
    • Son VIH-positivos.
    • Tienen un recuento de células CD4 de 300/mm3 ó más, durante los 45 días anteriores al ingreso al estudio.
    • Reciben un tratamiento combinado contra el VIH o comienzan a tomarlo en el momento de iniciarse el estudio.
    • Tienen por lo menos 18 años de edad.

Criterios de exclusión

    Los pacientes no podrán participar en este estudio si:
    • Han recibido antes interleucina-2 (IL-2).
    • Tienen una clase de cáncer que requiere quimioterapia.
    • Durante el año pasado presentaron indicios de una enfermedad clínica relacionada con cualquier enfermedad que define el diagnóstico de SIDA u otros trastornos específicos como la quemadura de sapo (herpes zoster) o la infección causada por el parásito Trypanosoma cruzi (conocida como enfermedad de Chagas), que produce fiebre y problemas del hígado, el bazo y el corazón. (Este estudio ha sido modificado. Anteriormente, los pacientes no podían participar si tenían un historial de cualquier enfermedad que define el diagnóstico de SIDA u otros trastornos específicos.)
    • En los 45 días anteriores al inicio del estudio, han usado determinados medicamentos, como cortisona, u otros que afectan al sistema inmunitario.
    • Tienen un trastorno del sistema nervioso que requiere medicamentos contra las convulciones.
    • Tienen una enfermedad en que el sistema inmunitario se ataca a sí mismo o una enfermedad inflamatoria, como una inflamación intestinal (i.e., la enfermedad de Crohn o colitis ulcerosa), psoriasis, neuritis óptica, o cualquier enfermedad en que el sistema inmunitario se ataca a sí mismo o una enfermedad inflamatoria con complicaciones que resulten potencialmente mortal.
    • Están embarazadas o dando el pecho.

Centros de estudio/contactos

California

    VA Greater Los Angeles Healthcare System, Infectious Diseases Section CRS, Los Angeles, California, 90073, United States

    Dr. M. Estes Med. Practice CRS, Mill Valley, California, 94941-3013, United States

    Dr. Robert Scott Med. Practice CRS, Oakland, California, 94609, United States

    East Bay AIDS Ctr. CRS, Oakland, California, 94705, United States

    Dr. Shawn Hassler Med. Practice CRS, San Francisco, California, 94102, United States

    Positive Health Program Clinic (San Francisco Gen. Hosp.) CRS, San Francisco, California, 94110-0242, United States

    Positive Health Practice West/ Dr. Steve Deeks CRS, San Francisco, California, 94110, United States

    Dr. William Owen Med. Practice CRS, San Francisco, California, 94114-1010, United States

    Dr. Martin Mass Med. Practice CRS, San Francisco, California, 94114, United States

    San Francisco VAMC, Infectious Diseases Clinic CRS, San Francisco, California, 94121, United States

    UCSF PHP, Gen. Internal Medicine Practice CRS, San Francisco, California, 94143, United States

    Castro-Mission Health Ctr. CRS, San Francisco, California, 94144, United States

    Dr. Virginia Cafaro Med. Practice CRS, San Francisco, California, 94144, United States

Colorado

    Denver Infectious Diseases Consultants CRS, Denver, Colorado, 80204-4507, United States

    Denver Public Health CRS, Denver, Colorado, 80204-4507, United States

    Univ. of Colorado Health Science Ctr. CRS, Denver, Colorado, 80204-4507, United States

District of Columbia

    Whitman-Walker Clinic CRS, Washington, District of Columbia, 20009, United States

    George Washington Univ. Med. Ctr. Infectious Diseases - Clinical Trials Unit CRS, Washington, District of Columbia, 20037, United States

    Walter Reed Army Med. Ctr., Infectious Disease Clinic CRS, Washington, District of Columbia, 20307, United States

    Washington DC VAMC, Washington Regional AIDS Program, Infectious Diseases CRS, Washington, District of Columbia, 20422, United States

    Dr. Timothy A. Price Med. Practice CRS, Washington, District of Columbia, 20422, United States

Florida

    Miami VAMC CRS, Miami, Florida, 33125, United States

    Univ. of Miami, Infectious Diseases Clinical Research Unit CRS, Miami, Florida, 33136, United States

Georgia

    ARCA, Central Clinc CRS, Atlanta, Georgia, 30308, United States

    Emory Univ. Crawford Long Hosp. CRS, Atlanta, Georgia, 30308, United States

    Atlanta VAMC CRS, Decatur, Georgia, 30033, United States

Illinois

    Klein & Slotten Medical Associates CRS, Chicago, Illinois, 60610, United States

    Jesse Brown VAMC CRS, Chicago, Illinois, 60612, United States

    Univ. of Illinois Family Ctr. for Infectious Disease CRS, Chicago, Illinois, 60612, United States

    Lakeshore Infectious Disease Associates CRS, Chicago, Illinois, 60657, United States

    North Side Family Medicine CRS, Chicago, Illinois, 60657, United States

    Northwestern Memorial Physicians Group CRS, Chicago, Illinois, 60657, United States

Louisiana

    Med. Ctr. of Louisiana at New Orleans, HIV Outpatient Clinics CRS, New Orleans, Louisiana, 70112, United States

    Tulane University Health Sciences Center, Louisiana Community AIDS Research Program(LaCARP) CRS, New Orleans, Louisiana, 70112, United States

    New Orleans VAMC CRS, New Orleans, Louisiana, 70146, United States

Maryland

    NIH Clinical Ctr., NIAID HIV Clinic CRS, Bethesda, Maryland, 20814-9692, United States

    National Naval Med. Ctr., Infectious Diseases Special Immunology Clinic CRS, Bethesda, Maryland, 208995000, United States

Michigan

    Henry Ford Hosp. CRS, Detroit, Michigan, 208995000, United States

    Wayne State Univ. CRS, Detroit, Michigan, 208995000, United States

    St. John Hosp. & Med. Ctr., Infectious Diseases Dept. CRS, Grosse Pointe Woods, Michigan, 48236, United States

    William Beaumont Hosp., Infectious Disease Research CRS, Royal Oak, Michigan, 48073, United States

Minnesota

    Abbott Northwestern Hosp., Clinic 42 CRS, Minneapolis, Minnesota, 55404, United States

    Mayo Clinic INSIGHT CRS, Rochester, Minnesota, 55905, United States

New Jersey

    Cooper Univ. Hosp. CRS, Camden, New Jersey, 07754, United States

    ID Care Inc. - Hillsborough CRS, Hillsborough, New Jersey, 08844, United States

    Jersey Shore Univ. Med. Ctr. CRS, Neptune, New Jersey, 07754, United States

    New Jersey Community Research Initiative, Jeffrey Bomser Clinic CRS, Newark, New Jersey, 07103, United States

    Cathedral Healthcare System, St. Michael's Med. Ctr. CRS, Newark, New Jersey, 07103, United States

    St. Joseph's Hosp. & Med. Ctr. of New Jersey CRS, Paterson, New Jersey, 07103, United States

    Raritan Bay Med. Ctr., Perth Amboy Division CRS, Perth Amboy, New Jersey, 08861, United States

    ID Care - Randolph CRS, Randolph, New Jersey, 07869, United States

    Infectious Disease Specialists of N.J., North Jersey Community Research Initiative CRS, Union, New Jersey, 07083, United States

    The Early Intervention Program at Kennedy Hosp. CRS, Voorhees, New Jersey, 08043, United States

New York

    Jacobi Med. Ctr., Ambulatory Care Pavillion CRS, Bronx, New York, 10461, United States

    Bronx VAMC CRS, Bronx, New York, 10468, United States

    St. Vincent Hosp. & Med. Ctr. CRS, New York, New York, 10011, United States

    Harlem Hospital Ctr./Columbia University CRS (Gordin CTU), New York, New York, 10037, United States

Oregon

    Oregon Health & Sciences Univ. Internal Medicine (L-475) CRS, Portland, Oregon, 97201, United States

    Multnomah County Health Dept., HIV Health Services Ctr. CRS, Portland, Oregon, 97204, United States

    The Research & Education Group-Portland CRS, Portland, Oregon, 97209, United States

    Providence Portland Med. Ctr., Ambulatory Care and Education Ctr. CRS, Portland, Oregon, 97213, United States

    Kaiser Immune Deficiency Clinic of Portland CRS, Portland, Oregon, 97227, United States

    Legacy Clinic Emanuel CRS, Portland, Oregon, 97301, United States

    Salem Hosp. CRS, Salem, Oregon, 97301, United States

    Kaiser Permanente Lancaster Clinic CRS, Salem, Oregon, 97305, United States

Pennsylvania

    Temple Univ. School of Medicine CRS, Philadelphia, Pennsylvania, 19140, United States

Texas

    Michael E. DeBakey VAMC CRS, Houston, Texas, 77030, United States

    Northwest Clinic CRS, Houston, Texas, 77030, United States

    Thomas Street Clinic CRS, Houston, Texas, 77030, United States

    Univ. Clinical Research Ctr., Memorial Hermann Hosp. CRS, Houston, Texas, 77030, United States

    Legacy Community Health Services, Inc., Montrose Clinic, Inc., Houston, Texas, 77030, United States

    South Texas Veterans Health Care System, Immunosuppression Clinic CRS, San Antonio, Texas, 78284, United States

Virginia

    Hanover Med. Park (Mechanicsville, VA) CRS, Mechanicsville, Virginia, 23116, United States

    Naval Med. Ctr. Portsmouth CRS, Portsmouth, Virginia, 23708, United States

    CrossOver Health Ctr. CRS, Richmond, Virginia, 23224, United States

    South Richmond Health Care Ctr. CRS, Richmond, Virginia, 23224, United States

    Hunter Holmes McGuire VAMC CRS, Richmond, Virginia, 23249, United States

    Virginia Commonwealth Univ. Medical Ctr. CRS, Richmond, Virginia, 23249, United States

Buenos Aires

    Hosp. de Clinicas Jose de San Martin, Div. Infectologia CRS, Ciudad de Buenos Aires, Buenos Aires, 1020, Argentina

    Hosp. Italiano de Buenos Aires, Infectious Diseases Section CRS, Ciudad de Buenos Aires, Buenos Aires, 1199, Argentina

    Hosp. Gen. de Agudos JM Ramos Mejia, Servicio de Inmunocomprometidos CRS, Ciudad de Buenos Aires, Buenos Aires, 1221, Argentina

    Hospital de Infecciosas F.J. Muniz CRS, Ciudad de Buenos Aires, Buenos Aires, 1282, Argentina

    Funcei Crs, Ciudad de Buenos Aires, Buenos Aires, 1425, Argentina

    Hosp. Gen. de Agudos Juan A. Fernandez CRS, Ciudad de Buenos Aires, Buenos Aires, 1425, Argentina

    Hosp. Gen. de Agudos 'Teodoro Alvarez' CRS, Ciudad de Buenos Aires, Buenos Aires, 1425, Argentina

    Hospital Nacional Professor Alejandro Posadas CRS, El Palomar, Buenos Aires, 1706, Argentina

    Hospital Interzonal de Agudos Oscar Alende, Sala de Infectologia CRS, Mar del Plata, Buenos Aires, 7600, Argentina

Provincia de Santa Fe

    Caici Crs, Rosario, Provincia de Santa Fe, 2000, Argentina

    Hosp. Rawson CRS, Cordoba, Provincia de Santa Fe, 5000, Argentina

    Hosp. Interzonal de Agudos San Juan de Dios CRS, La Plata, Provincia de Santa Fe, 1900, Argentina

    Hosp. Central, Immunology Dept. CRS, Mendoza, Provincia de Santa Fe, 5500, Argentina

Australian Capital Territory

    Interchange General Practice CRS, Canberra, Australian Capital Territory, 2601, Australia

    Canberra Hosp., Canberra Sexual Health Clinic CRS, Woden, Australian Capital Territory, 2606, Australia

New South Wales

    Burwood Road Gen. Practice CRS, Burwood, New South Wales, 2134, Australia

    St. Vincent's Hospital CRS, Darlinghurst, New South Wales, 2010, Australia

    Taylor Square Private Clinic CRS, Darlinghurst, New South Wales, 2010, Australia

    Holdsworth House Gen. Practice CRS, Darlinghurst, New South Wales, 2010, Australia

    John Hunter Hosp., Immunology & Infectious Diseases Unit CRS, Newcastle, New South Wales, 2305, Australia

    407 Doctors CRS, Surry Hills, New South Wales, 2010, Australia

    Albion Street Ctr. CRS, Surry Hills, New South Wales, 2010, Australia

Queensland

    Queensland Health - AIDS Med. Unit CRS, Brisbane, Queensland, 2010, Australia

    Cairns Base Hosp., Sexual Health Services CRS, Cairns, Queensland, 4870, Australia

    Gladstone Road Medical Ctr. CRS, Highgate Hill, Queensland, 4101, Australia

    Nambour Gen. Hosp. CRS, Nambour, Queensland, 4560, Australia

South Australia

    Royal Adelaide Hosp. CRS, Adelaide, South Australia, 5000, Australia

    The Care & Prevention Programme CRS, Adelaide, South Australia, 5000, Australia

Victoria

    Carlton Clinic CRS, Carlton, Victoria, 5000, Australia

    The Alfred Hosp., Clinical Research - Infectious Diseases Unit CRS, Melbourne, Victoria, 3004, Australia

    Prahran Market Clinic CRS, Melbourne, Victoria, 3004, Australia

    Northcote Clinic CRS, Northcote, Victoria, 3070, Australia

    Royal Melbourne Hosp., Victorian Infectious Diseases Service CRS, Parkville, Victoria, 3052, Australia

    The Ctr. Clinic INSIGHT CRS, St. Kilda, Victoria, 3052, Australia

Western Australia

    Royal Perth Hospital CRS, Perth, Western Australia, 3052, Australia

    Gold Coast Sexual Health Clinic CRS, Miami, Queensland, Western Australia, 3052, Australia

    Univ. of Vienna Med. School, Div. of Allergy, Immunology & Infectious Diseases - Sued B CRS, Vienna, Western Australia, A-1090, Austria

    SMZ Baumgartner Hoehe, Immunambulanz Pavillion Wienerwald Parterre CRS, Wien, Western Australia, A-1140, Austria

    Ctr. Hospitalier Universitaire, St Pierre, Div. of Infectious Diseases (PL5) CRS, Bruxelles, Western Australia, A-1140, Belgium

Sao Paulo

    Centro de Referencia e Treinamento em DST/AIDS - Sao Paulo CRS, Vila Mariana, Sao Paulo, 04121-000, Brazil

    Instituto de Infectologia Emilio Ribas CRS, Sao Paulo, Sao Paulo, 01246-900, Brazil

    Universidade Federal de Sao Paulo,IDIPA-Instituto Paulista de Doencas Infecciosas e Parasitarias CRS, Sao Paulo, Sao Paulo, 04040-002, Brazil

Alberta

    Univ. of Alberta Hosp., Clinical Research Office CRS, Edmonton, Alberta, 04040-002, Canada

British Columbia

    Cool Aid Community Health Ctr. CRS, Victoria, British Columbia, 04040-002, Canada

Nova Scotia

    Q.E. II Health Sciences Ctr., Captial District Authority, Victoria Gen. Hosp. CRS, Halifax, Nova Scotia, 04040-002, Canada

Ontario

    McMaster Univ. Med. Ctr. Hamiton Health Sciences, SIS Clinic CRS, Hamilton, Ontario, 04040-002, Canada

    St. Joseph's Health Ctr. of London, HIV Care Programme CRS, London, Ontario, N5Y 3H6, Canada

    Ottawa Hosp., Gen. Campus CRS, Ottawa, Ontario, K1H 8L6, Canada

    The HAVEN Program, Sudbury Regional Hosp., Laurentian Site CRS, Sudbury, Ontario, P3E 5J1, Canada

    Toronto Gen. Hosp. Infectious Diseases CRS, Toronto, Ontario, P3E 5J1, Canada

    Windsor Regional Hosp., HIV Care Program CRS, Windsor, Ontario, P3E 5J1, Canada

Quebec

    CHUS - Hopital Fleurimont, Centre de Recherche Clinique CRS, Fleurimont, Quebec, J1H 5N4, Canada

    Hopital Maisonneuve-Rosemont, Dept. de Microbiologie CRS, Montreal, Quebec, H1T 2M4, Canada

    CHUM - Campus Notre-Dame CRS, Montreal, Quebec, H2L 4M1, Canada

    Royal Victoria Hosp., Montreal Chest Institute CRS, Montreal, Quebec, H2L 4M1, Canada

    Centre Hospitalier Universitaire de Quebec - CHUL, Centre de Recherche en Indectiologie CRS, Sainte-Foy, Quebec, H2L 4M1, Canada

Saskatchewan

    Royal Univ. Hosp. CRS, Saskatoon, Saskatchewan, S7N 0W8, Canada

    Aalborg Hosp., Dept. of Infectious Diseases CRS, Aalborg, Saskatchewan, S7N 0W8, Denmark

    Skejby Sygehus, Department of Infectious Diseases Q (ambulatoriet) CRS, Aarhus, Saskatchewan, DK-8200, Denmark

    Rigshospitalet, Department of Infectious Diseases, M5112 CRS, Copenhagen, Saskatchewan, DK-8200, Denmark

    Hvidovre Univ. Hosp., Dept. of Infectious Diseases CRS, Hvidovre, Saskatchewan, DK-8200, Denmark

    Odense Univ. Hosp., Med. Dept. C CRS, Odense, Saskatchewan, DK-8200, Denmark

Pringy

    Centre Hospitalier de la Region Annecienne, Service des Maladie Infectieuses CRS, Cedex, Pringy, DK-8200, France

    CHRU d'Angers, Service de Maladies Infectieuses CRS, Angers, Pringy, 49033, France

    Hopital Saint-Jacques, Service des Maladies Infectieuses et Tropicales CRS, Besancon, Pringy, 25030, France

    Hopital Avicenne, Service de Medecine B CRS, Bobigny, Pringy, 93009, France

    Hopital Antoine Beclere Service d'Immunologie Clinique CRS, Clamart, Pringy, 92141, France

    Hopital Louis Mourier, Service de Medecine Interne CRS, Colombes, Pringy, 92701, France

    Hopital Henri Mondor, Immunopathologie Clinique CRS, Creteil, Pringy, 94010, France

    Hopital Raymond Poincare - Vidal 2, Service des Maladies Infectieuses et Tropicales CRS, Garches, Pringy, 92380, France

    Hopital de Bicetre, Service de Medecine Interne CRS, Le Kremlin-Bicetre, Pringy, 94275, France

    Hopital Sainte Marguerite, CISIH Hopital de Jour CRS, Marseille, Pringy, 13009, France

    Hopital de la Conception, Service des Maladies Infectieuses CRS, Marseille, Pringy, 13385, France

    Hopital Gui de Chauliac, Service des Maladies Infectieuses et Tropicales CRS, Montpellier, Pringy, 34295, France

    Hopital de l'Archet 1, Service de Medecine Interne 2 Hematologie Clinique CRS, Nice, Pringy, 06202, France

    Hopital Saint-Antoine, Service de Maladies Infectieuses CRS, Paris, Pringy, 75012, France

    Hopital de La Salpetriere, Service de Medecine Interne CRS, Paris, Pringy, 75651, France

    Hopital Cochin, Service de Medecine Interne 2 CRS, Paris, Pringy, 75674, France

    Hopital Necker, Service des Maladies Infectieuses CRS, Paris, Pringy, 75743, France

    Hopital Europeen Georges Pompidou, Service d'Immunologie Clinique CRS, Paris, Pringy, 75908, France

    Hopital Tenon, Service de Maladies Infectieuses et Tropicales CRS, Paris, Pringy, 75970, France

    C.H.U. Bichat - Claude Bernard Service des Maladies Infectieuses et Tropicales CRS, Paris, Pringy, 75970, France

    CHRU de Strasbourg (France) CRS, Strasbourg, Pringy, 67091, France

    Hopital Foch, Service de Medecine Interne CRS, Suresenes, Pringy, 92151, France

    Univ. Hosp. Charite, Dept of Infectious Diseases CRS, Berlin, Pringy, 13353, Germany

    Ruhr-Univ., Interdiszipl. Immunolog. Ambulanz CRS, Bochum, Pringy, 13353, Germany

    Medizinische Universitaetsklinik - Bonn, Immunologische Ambulanz CRS, Bonn, Pringy, 53105, Germany

    Ctr. for HIV & Hepatogastroenterology, HIV Specialised Practice (Private Practice) CRS, Duesseldorf, Pringy, 40237, Germany

    Johann Wolfgang Goethe Univ. Hosp., Infektionsambulanz CRS, Frankfurt, Pringy, 60590, Germany

    IPM Study Ctr. (Hamburg) CRS, Hamburg, Pringy, 60590, Germany

    Univ. Hosp. Heidelberg, Dept. of Dermatology CRS, Heidelberg, Pringy, 69115, Germany

    Klinik I fur Innere Medizin der Universitat zu Koln, Studienburo fur Infektiologie u. HIV CRS, Koln, Pringy, 69115, Germany

    Klinikum Innenstadt, Infektionsambulanz und Tagesklinik CRS, Munchen, Pringy, 69115, Germany

    Univ. of Wuerzburg, Medizinische Poliklinik, Schwerpunkt Hepatologie/Infektiologie CRS, Wuerzburg, Pringy, 69115, Germany

    St. James' Hosp., Guide Clinic CRS, Dublin, Pringy, 69115, Ireland

    Rambam Med. Ctr., Immunology, Allergy & AIDS Institute, B. Rappaport Faculty of Medicine, Technion, Haifa, Pringy, 31096, Israel

    Kaplan Med. Ctr., Ben Ari Institute of Clinical Immunology CRS, Rehovot, Pringy, 31096, Israel

    Tel Aviv Sourasky Med. Ctr., Clinical Immunology Unit and AIDS Ctr. CRS, Tel Aviv, Pringy, 64239, Israel

    Civili di Brescia, 1st Division of Infectious Diseases CRS, Brescia, Pringy, 25123, Italy

    Civili di Brescia, Dept of Infectious & Tropical Disease, Hosp.Spedali Civili of Brescia CRS, Brescia, Pringy, 25123, Italy

    Ospedale S. Maria Annunziata, U.O. Malattie Infettive CRS, Firenze, Pringy, 50011, Italy

    Ospedale San Raffaele, Centro San Luigi - Divisione Malattie Infettive CRS, Milano, Pringy, 50011, Italy

    Univ. of Milan, Ospedale Luigi Sacco, Institute of Infectious and Tropical Diseases CRS, Milano, Pringy, 50011, Italy

    Universita degli Studi di Modena e Reggio Emilia, Clinica delle Malattie Infettive e Tropicali CRS, Modena, Pringy, 50011, Italy

    San Matteo Hospital - University of Pavia, Division of Infectious and Tropical Diseases CRS, Pavia, Pringy, 27100, Italy

    Universita La Sapienza, Clinica Universita La Sapienza CRS, Roma, Pringy, 00185, Italy

    Osaka National Hosp. AIDS Ctr., Clinical Research Institute CRS, Osaka, Pringy, 00185, Japan

    International Med. Ctr. of Japan CRS, Tokyo, Pringy, 00185, Japan

    Univ. of Tokyo, Research Hosp. of the Institute of Medical Science CRS, Tokyo, Pringy, 00185, Japan

    Univ. Hosp. Ctr. of the Med. School of Casablanca, Infectious Diseases Unit CRS, Casablanca, Pringy, 00185, Morocco

    OLVG -- locatie Prinsengracht, Dept. of Internal Medicine II CRS, Amsterdam, Pringy, 1017 JZ, Netherlands

    Academisch Medisch Centrum CRS, Amsterdam, Pringy, 1150 AZ, Netherlands

    Stichting Medisch Centrum Jan van Goyen, Dept. of Internal Medicine CRS, Amsterdam, Pringy, 1150 AZ, Netherlands

    Groningen Univ. Hosp., Department of Internal Medicine CRS, Groningen, Pringy, 9713 GZ, Netherlands

    Kennemer Gasthuis, Lokatie EG CRS, Haarlem, Pringy, 9713 GZ, Netherlands

    St. Elisabeth Ziekenhuis CRS, Tilburg, Pringy, 9713 GZ, Netherlands

    Ulleval Hosp., Dept. of Infectious Diseases CRS, Oslo, Pringy, 9713 GZ, Norway

    Szpital Specjalistyczny, Osrodek Diagnostyki i Terapii AIDS CRS, Chorzow, Pringy, 41-500, Poland

    Pomeranian Academy of Medicine (PAM), Dept. of Infectious Diseases and Hepatology CRS, Szczecin, Pringy, 71-455, Poland

    Wojewodzki Szpital Zakazny CRS, Warsaw, Pringy, 01-201, Poland

    Wroclaw Univ., School of Med., Dept. of Infectious Diseases, Liver Diseases and AIDS CRS, Wroclaw, Pringy, 51-171, Poland

    Hospital de Cascais, HDDI, Departamento Medicina Interna CRS, Cascais, Pringy, 2775, Portugal

    Hosp. de Egas Moniz, Servicio de Infecciologia e Medicina Tropical CRS, Lisboa, Pringy, 1349-019, Portugal

    Hosp. de Santa Maria, Servico de Doencas Infecciosas CRS, Lisboa, Pringy, 1349-019, Portugal

    Tan Tock Seng Hosp., Infectious Diseases Research Ctr. CRS, Singapore, Pringy, 308433, Singapore

Guipuzcoa

    Hosp. Donostia CRS, San Sebastian, Guipuzcoa, E-20011, Spain

    Hosp. Juan Canalejo, Dept. of Internal Medicine CRS, A Coruna, Guipuzcoa, E-20011, Spain

    Hosp. Santa Creu i Sant Pau, Servicio de Medicina Interna CRS, Barcelona, Guipuzcoa, E-08025, Spain

    Hosp. Clinico de Barcelona CRS, Barcelona, Guipuzcoa, E-08036, Spain

    Hosp. del Mar, Internal Medicine-Infectious Diseases CRS, Barcelona, Guipuzcoa, E-08036, Spain

    Hosp. Universitari Germans Trias i Pujol, HIV Unit and Retrovirology Lab. CRS, Barcelona, Guipuzcoa, E-08036, Spain

    Hosp. Universitario Gregorio Maranion, Microbiology & Infectious Diseases Unit CRS, Madrid, Guipuzcoa, E-28007, Spain

    Centro de Investigacion Carlos III, Infectious Diseases Dept. CRS, Madrid, Guipuzcoa, E-28029, Spain

    Hosp. Severo Ochoa, Internal Medicine and Infectious Diseases CRS, Madrid, Guipuzcoa, E-28911, Spain

    Hosp. 12 de Octubre, Pabellon de Medicina Communitaria CRS, Madrid, Guipuzcoa, E-28911, Spain

    Hosp. Clinico San Carlos CRS, Madrid, Guipuzcoa, E-28911, Spain

    Hosp. la Princesa, Internal Medicine and Infectious Diseases Service CRS, Madrid, Guipuzcoa, E-28911, Spain

    Hosp. Ramon y Cajal (Madrid) CRS, Madrid, Guipuzcoa, E-28911, Spain

    Hosp. Universitario La Paz CRS, Madrid, Guipuzcoa, E-28911, Spain

    Hosp. Universitario Principe de Asturias CRS, Madrid, Guipuzcoa, E-28911, Spain

    Hosp. Universitario Morales Meseguer CRS, Murcia, Guipuzcoa, E-28911, Spain

    Hosp. Virgen del Rocio, Infectious Diseases Service CRS, Sevilla, Guipuzcoa, E-41013, Spain

    Karolinska Univ. Hosp. Huddinge, Dept. of Infectious Diseases CRS, Stockholm, Guipuzcoa, SE-141 86, Sweden

    Venhalsan, Soder Hosp., Dept. of Infectious Diseases, Karolinska Univ. Hosp. CRS, Stockholm, Guipuzcoa, SE-141 86, Sweden

Ticino

    Regional Hosp. of Lugano (Sede Civico), Ospedale Civico di Lugano, Infectious Diseases Unit CRS, Lugano, Ticino, CH-6903, Switzerland

Ratchathewi

    Siriraj Hosp., Mahidol Univ. INSIGHT CRS, Bangkok, Ratchathewi, 10700, Thailand

    Chulalongkorn Univ. Hosp., HIV-NAT Research Collaboration CRS, Bangkok, Ratchathewi, 10700, Thailand

    Chiang Rai Regional Hosp. INSIGHT CRS, Chiangrai, Ratchathewi, 10700, Thailand

    Chonburi Regional Hosp., Dept. of Internal Medicine CRS, Chonburi, Ratchathewi, 10700, Thailand

    Khon Kaen Univ., Srinagarind Hosp., Div. of Infectious Diseases & Tropical Medicine, Dept. of Medici, Khon Kaen, Ratchathewi, 40002, Thailand

Brighton

    Brighton & Sussex Univ. Hosp. NHS Trust, HIV Research Office CRS, Elm Grove, Brighton, BN2 1ES, United Kingdom

Northern Ireland

    Royal Victoria Hosp. Dept. of Genitourinary Medicine CRS, Belfast, Northern Ireland, BN2 1ES, United Kingdom

Oxford

    Churchill Hosp. John Warin Ward CRS, Headington, Oxford, OX3 9DU, United Kingdom

Scotland

    Western Gen. Hosp., Regional Infectious Diseases Unit CRS, Edinburgh, Scotland, OX3 9DU, United Kingdom

    Gartnaval Gen. Hosp., Brownlee Ctr. CRS, Glasgow, Scotland, OX3 9DU, United Kingdom

    Heartlands Hosp. Dept. of Infection & Tropical Disease Outpatients CRS, Birmingham, Scotland, B9 5ST, United Kingdom

    Royal Devon & Exeter NHS Foundation Trust, Heavitree Hosp., Dept. of GU Medicine CRS, Exeter, Scotland, EX1 2ED, United Kingdom

    Leicester Royal Infirmary, Dept. of Infection & Tropical Medicine CRS, Leicester, Scotland, LE1 5WW, United Kingdom

    Royal London Hosp., Ambrose King Ctr. CRS, London, Scotland, E1 1BB, United Kingdom

    St. Thomas' Hosp., Dept. of GU Medicine CRS, London, Scotland, SE1 7EH, United Kingdom

    St. George's Hosp. Clinical Infection UnitCRS, London, Scotland, SW17 0RE, United Kingdom

    Chelsea & Westminster Hosp., St. Stephens Ctr. CRS, London, Scotland, SW17 0RE, United Kingdom

    King's College Hosp., Caldecot Ctr. Dept. of Sexual Health CRS, London, Scotland, SW17 0RE, United Kingdom

    Royal Free Hosp., Dept. of Infection & Immunity, Ian Charleson Day Ctr. CRS, London, Scotland, SW17 0RE, United Kingdom

    St. Bartholomew's Hosp., Infection & Immunity Clinical Group CRS, London, Scotland, SW17 0RE, United Kingdom

    St. Mary's Hosp. of London, Imperial College School of Medicine CRS, London, Scotland, SW17 0RE, United Kingdom

    Univ. College London Med. School, Ctr. for Sexual Health & HIV Research CRS, London, Scotland, SW17 0RE, United Kingdom

    Newcastle Gen. Hosp., Dept of Infection & Tropical Medicine CRS, Newcastle Upon Tyne, Scotland, NE4 6BE, United Kingdom

    Edith Cavell Hosp. Dept. of Sexual Health, Clinic E CRS, Peterborough, Scotland, NE4 6BE, United Kingdom

    Royal Hallamshire Hosp., Dept. of GU Medicine Communicable Diseases Unit CRS, Sheffield, Scotland, S10 2JF, United Kingdom

Actualizado: 13 de octubre del 2004

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